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ASXL1 antibody

GTX127284
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetASXL1
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Overview

  • Supplier
    GeneTex
  • Product Name
    ASXL1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:1000-1:10000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID171023
  • Target name
    ASXL1
  • Target description
    ASXL transcriptional regulator 1
  • Target synonyms
    BOPS, MDS, polycomb group protein ASXL1, additional sex combs like 1, transcriptional regulator, additional sex combs like transcriptional regulator 1, putative Polycomb group protein ASXL1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ8IXJ9
  • Protein Name
    Polycomb group protein ASXL1
  • Scientific Description
    This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Moon S, Im SK, Kim N, et al. Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis. Cell Death Dis. 2018,9(11):1118. doi: 10.1038/s41419-018-1171-z
    Read this paper
  • Youn HS, Kim TY, Park UH, et al. Asxl1 deficiency in embryonic fibroblasts leads to cellular senescence via impairment of the AKT-E2F pathway and Ezh2 inactivation. Sci Rep. 2017,7(1):5198. doi: 10.1038/s41598-017-05564-x
    Read this paper
  • Moon S, Um SJ, Kim EJ. Role of Asxl1 in kidney podocyte development via its interaction with Wtip. Biochem Biophys Res Commun. 2015,466(3):560-6. doi: 10.1016/j.bbrc.2015.09.077
    Read this paper

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Figure 1. Western blot analysis of ASXL1 using anti-ASXL1 antibody (A01099-1). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. Lane 1: human COLO-32 whole cell lysates, Lane 2: human Jurkat whole cell lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-ASXL1 antigen affinity purified polyclonal antibody (Catalog # A01099-1) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for ASXL1 at approximately 165KD. The expected band size for ASXL1 is at 165KD.
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