AT9283 [896466-04-9]
SYN-1011
CAS Number896466-04-9
Product group Chemicals
Estimated Purity>95%
Molecular Weight381.4
Overview
- SupplierSYNkinase
- Product NameAT9283 [896466-04-9]
- Delivery Days Customer10
- CAS Number896466-04-9
- CertificationResearch Use Only
- Estimated Purity>95%
- Molecular FormulaC19H23N7O2
- Molecular Weight381.4
- Scientific DescriptionAurora kinases play a key role in the regulation of mitosis and in recent years have become attractive targets for the treatment of cancer. AT9283 is a powerful inhibitor of Aurora A and B kinases as well as several other important kinases including JAK2 and Abl (T315I). AT9283 has also been shown effective in mouise xenograft models and has been studied as a possible clinical candidate. Effective IC(50) doses for Aurora kinases are in the low 2-3nM range, and inhibition of a number of other kinases including JAK2 has been reported at 1-10nM. - Chemical. CAS: 896466-04-9. Formula: C19H23N7O2. MW: 381.4. Aurora kinases play a key role in the regulation of mitosis and in recent years have become attractive targets for the treatment of cancer. AT9283 is a powerful inhibitor of Aurora A and B kinases as well as several other important kinases including JAK2 and Abl (T315I). AT9283 has also been shown effective in mouise xenograft models and has been studied as a possible clinical candidate. Effective IC(50) doses for Aurora kinases are in the low 2-3nM range, and inhibition of a number of other kinases including JAK2 has been reported at 1-10nM.
- Storage Instruction2°C to 8°C
- UNSPSC51202000