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ProductsBack/AT9283 [896466-04-9]
Chemical Structure
Chemical Structure
Chemical Structure

AT9283 [896466-04-9]

SYN-1011
SYNkinase
CAS Number896466-04-9
Product group Chemicals
Estimated Purity>95%
Molecular Weight381.4
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Overview

  • Supplier
    SYNkinase
  • Product Name
    AT9283 [896466-04-9]
  • Delivery Days Customer
    10
  • CAS Number
    896466-04-9
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C19H23N7O2
  • Molecular Weight
    381.4
  • Scientific Description
    Aurora kinases play a key role in the regulation of mitosis and in recent years have become attractive targets for the treatment of cancer. AT9283 is a powerful inhibitor of Aurora A and B kinases as well as several other important kinases including JAK2 and Abl (T315I). AT9283 has also been shown effective in mouise xenograft models and has been studied as a possible clinical candidate. Effective IC(50) doses for Aurora kinases are in the low 2-3nM range, and inhibition of a number of other kinases including JAK2 has been reported at 1-10nM. - Chemical. CAS: 896466-04-9. Formula: C19H23N7O2. MW: 381.4. Aurora kinases play a key role in the regulation of mitosis and in recent years have become attractive targets for the treatment of cancer. AT9283 is a powerful inhibitor of Aurora A and B kinases as well as several other important kinases including JAK2 and Abl (T315I). AT9283 has also been shown effective in mouise xenograft models and has been studied as a possible clinical candidate. Effective IC(50) doses for Aurora kinases are in the low 2-3nM range, and inhibition of a number of other kinases including JAK2 has been reported at 1-10nM.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    51202000