![WB analysis of irradiate or peroxidase treated human fibroblast lysate using GTX30636 ATM (phospho Ser1981) antibody [10H11.E12]. WB analysis of irradiate or peroxidase treated human fibroblast lysate using GTX30636 ATM (phospho Ser1981) antibody [10H11.E12].](https://www.genetex.com/upload/website/prouct_img/normal/GTX30636/GTX30636_1445_WB_w_23060722_646.webp)
WB analysis of irradiate or peroxidase treated human fibroblast lysate using GTX30636 ATM (phospho Ser1981) antibody [10H11.E12].
ATM (phospho Ser1981) antibody [10H11.E12]
GTX30636
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetATM
Overview
- SupplierGeneTex
- Product NameATM (phospho Ser1981) antibody [10H11.E12] - Orthogonal Validated
- Delivery Days Customer9
- Application Supplier NoteWB: 1:1000. ICC/IF: 1:1000. IHC-P: 1:200. IP: 1:10 - 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID10H11.E12
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID472
- Target nameATM
- Target descriptionATM serine/threonine kinase
- Target synonymsAT mutated; A-T mutated; AT1; ATA; ataxia telangiectasia mutated; ATC; ATD; ATDC; ATE; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1
- HostMouse
- IsotypeIgG1
- Protein IDQ13315
- Protein NameSerine-protein kinase ATM
- Scientific DescriptionThe protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Combination treatment of cordycepin and radiation induces MA-10 mouse Leydig tumor cell death via ROS accumulation and DNA damage.Read more
- IL-6 signaling contributes to radioresistance of prostate cancer through key DNA repair-associated molecules ATM, ATR, and BRCA 1/2. Chen X et al., 2019 Jun, J Cancer Res Clin OncolRead more