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ATP6V1A antibody

Research Use Only
GTX110815
GeneTex
ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetATP6V1A
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Overview

  • Supplier
    GeneTex
  • Product Name
    ATP6V1A antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:1000-1:10000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.57 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID523
  • Target name
    ATP6V1A
  • Target description
    ATPase H+ transporting V1 subunit A
  • Target synonyms
    ARCL2D; ATP6A1; ATP6V1A1; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A; ATPase, H+ transporting, lysosomal, subunit A1; DEE93; H(+)-transporting two-sector ATPase, subunit A; H+-transporting ATPase chain A, vacuolar (VA68 type); HO68; IECEE3; VA68; vacuolar proton pump alpha subunit 1; vacuolar proton pump subunit alpha; V-ATPase 69 kDa subunit 1; V-ATPase A subunit 1; V-ATPase subunit A; Vma1; VPP2; V-type proton ATPase (V-ATPase) catalytic subunit A; V-type proton ATPase catalytic subunit A
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP38606
  • Protein Name
    V-type proton ATPase catalytic subunit A
  • Scientific Description
    This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Faulty autolysosome acidification in Alzheimers disease mouse models induces autophagic build-up of Abeta in neurons, yielding senile plaques. Lee JH et al., 2022 Jun, Nat Neurosci
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  • Fronto-temporal dementia risk gene TMEM106B has opposing effects in different lysosomal storage disorders. Perez-Canamas A et al., 2021, Brain Commun
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  • Thioredoxin-Interacting Protein Promotes Phagosomal Acidification Upon Exposure to Escherichia coli Through Inflammasome-Mediated Caspase-1 Activation in Macrophages. Yoon SJ et al., 2019, Front Immunol
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  • Novel c.G630A TCIRG1 mutation causes aberrant splicing resulting in an unusually mild form of autosomal recessive osteopetrosis. Zirngibl RA et al., 2019 Oct, J Cell Biochem
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  • TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation. Hashimoto Y et al., 2018 Jun, Genes Cells
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  • The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex. Deng Y et al., 2018 May 15, Hum Mol Genet
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  • Activity-independent targeting of mTOR to lysosomes in primary osteoclasts. Wang A et al., 2017 Jun 7, Sci Rep
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  • mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide. Matsumoto A et al., 2017 Jan 12, Nature
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  • Neuronal ceroid lipofuscinosis with DNAJC5/CSPalpha mutation has PPT1 pathology and exhibit aberrant protein palmitoylation. Henderson MX et al., 2016 Apr, Acta Neuropathol
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  • Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Jewell JL et al., 2015 Jan 9, Science
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