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ATP6V1A antibody

GTX110815
GeneTex
ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetATP6V1A
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Overview

  • Supplier
    GeneTex
  • Product Name
    ATP6V1A antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:1000-1:10000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.57 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID523
  • Target name
    ATP6V1A
  • Target description
    ATPase H+ transporting V1 subunit A
  • Target synonyms
    ARCL2D, ATP6A1, ATP6V1A1, DEE93, HO68, IECEE3, VA68, VPP2, Vma1, V-type proton ATPase catalytic subunit A, ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A, ATPase, H+ transporting, lysosomal, subunit A1, H(+)-transporting two-sector ATPase, subunit A, H+-transporting ATPase chain A, vacuolar (VA68 type), V-ATPase 69 kDa subunit 1, V-ATPase A subunit 1, V-ATPase subunit A, V-type proton ATPase (V-ATPase) catalytic subunit A, vacuolar proton pump alpha subunit 1, vacuolar proton pump subunit alpha, vacuolar-type H(+)-ATPase
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP38606
  • Protein Name
    V-type proton ATPase catalytic subunit A
  • Scientific Description
    This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

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  • Yoon SJ, Jo DH, Park SH, et al. Thioredoxin-Interacting Protein Promotes Phagosomal Acidification Upon Exposure to Escherichia coli Through Inflammasome-Mediated Caspase-1 Activation in Macrophages. Front Immunol. 2019,10:2636. doi: 10.3389/fimmu.2019.02636
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  • Zirngibl RA, Wang A, Yao Y, et al. Novel c.G630A TCIRG1 mutation causes aberrant splicing resulting in an unusually mild form of autosomal recessive osteopetrosis. J Cell Biochem. 2019,120(10):17180-17193. doi: 10.1002/jcb.28979
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  • Deng Y, Qin Y, Srikantan S, et al. The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex. Hum Mol Genet. 2018,27(10):1794-1808. doi: 10.1093/hmg/ddy095
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  • Wang A, Carraro-Lacroix LR, Owen C, et al. Activity-independent targeting of mTOR to lysosomes in primary osteoclasts. Sci Rep. 2017,7(1):3005. doi: 10.1038/s41598-017-03494-2
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  • Henderson MX, Wirak GS, Zhang YQ, et al. Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation. Acta Neuropathol. 2016,131(4):621-37. doi: 10.1007/s00401-015-1512-2
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  • Jewell JL, Kim YC, Russell RC, et al. Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Science. 2015,347(6218):194-8. doi: 10.1126/science.1259472
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