ATP8B1 Antibody

Cusabio

ATP8B1 Antibody

20

ImmunoFluorescence, ELISA

Research Use Only

Polyclonal

Unconjugated

ATP8B1

ATPase phospholipid transporting 8B1

ATPase, aminophospholipid transporter, class I, type 8B, member 1; ATPase, class I, type 8B, member 1; ATPIC; BRIC; E1-E2 ATPase; familial intrahepatic cholestasis type 1; FIC1; ICP1; P4-ATPase flippase complex alpha subunit ATP8B1; PFIC; PFIC1; phospholipid-transporting ATPase IC; probable phospholipid-transporting ATPase IC

Rabbit

IgG

Phospholipid-transporting ATPase IC

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May play a role in asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both. In cooperation with ABCB4 may be involved in establishing integrity of the canalicular membrane thus protecting hepatocytes from bile salts. Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine. Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity. Required for the preservation of cochlear hair cells in the inner ear. May act as cardiolipin transporter during inflammatory injury.

Human

-20°C or -80°C

41116161