ATR antibody

GeneTex

ATR antibody

9

WB: 1:500-1:3000. ICC/IF: 1:100-1:5000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

ATR

ATR checkpoint kinase

FCTCS, FRP1, MEC1, SCKL, SCKL1, serine/threonine-protein kinase ATR, ATR serine/threonine kinase, FRAP-related protein-1, MEC1, mitosis entry checkpoint 1, homolog, ataxia telangiectasia and Rad3-related protein

Rabbit

IgG

Serine/threonine-protein kinase ATR

The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq]

Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203