AURKC Antibody

Cusabio

AURKC Antibody

20

ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

AURKC

aurora kinase C

AIE2, AIK3, ARK3, AurC, HEL-S-90, SPGF5, STK13, aurora-C, aurora kinase C, ARK-3, aurora 3, aurora-related kinase 3, aurora/IPL1-related kinase 3, aurora/IPL1/EG2 protein 2, epididymis secretory protein Li 90, serine/threonine kinase 13 (aurora/IPL1-like), serine/threonine-protein kinase 13, serine/threonine-protein kinase aurora-C

Rabbit

IgG

Aurora kinase C

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at Ser-10 and Ser-28. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at Ser-228.

Human

-20°C or -80°C

41116161