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ProductsBack/Aurodox [12704-90-4]
Chemical Structure
Chemical Structure
Chemical Structure

Aurodox [12704-90-4]

Research Use Only
AG-CN2-0133
AdipoGen Life Sciences
CAS Number12704-90-4
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight811
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Aurodox
  • Delivery Days Customer
    10
  • CAS Number
    12704-90-4
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Hazard Information
    Warning
  • Molecular Formula
    C44H62N2O12
  • Molecular Weight
    811
  • Scientific Description
    Antibiotic [2,3] Protein biosynthesis inhibitor by binding to elongation factor Tu (EF-Tu) [4-7]. Type 3 secretion system (T3SS) inhibitor [8]. Growth promotor in poultry [1]. - Chemical. CAS: 12704-90-4. Formula: C44H62N2O12. MW: 811. Isolated from Streptomyces sp. K06-0806. Antibiotic Protein biosynthesis inhibitor by binding to elongation factor Tu (EF-Tu). Type 3 secretion system (T3SS) inhibitor. Growth promotor in poultry.
  • SMILES
    [H][C@@]1(O[C@@]([H])([C@H](C)[C@H](OC)C(\C)=C\C=C\CNC(=O)[C@@H](CC)[C@@]2(O)O[C@@]([H])(\C=C\C=C/C)C(C)(C)[C@@H](O)[C@H]2O)[C@@H](O)[C@H]1O)\C=C\C=C\C=C(/C)C(=O)C1=C(O)C=CN(C)C1=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • A New Antibiotic, X-5108, for Improved Growth and Feed Conversion in Poultry: W.L. Marusich, et al.; Poult. Sci. 53, 936 (1974)
  • Feedback inhibition of the synthesis of an antibiotic: aurodox (X-5108): C. Liu, et al.; J. Antibiot. 30, 244 (1977)
  • Increased production of the antibiotic aurodox (X-5108) by aurodox-resistant mutants: J. Unowsky & D.C. Hoppe; J. Antibiot. 31, 662 (1978)
  • Stimulation of Escherichia coli elongation factor Tu-dependent GTP hydrolysis by aminoacyl oligonucleotides in the presence of aurodox: P. Bhuta & S. Chladek; FEBS Lett. 122, 113 (1980)
  • Synthetic analogs of aurodox and kirromycin active on elongation factor Tu from Escherichia coli: G. Chinali; J. Antibiot. 34, 1039 (1981)
  • Effects of nucleotide- and aurodox-induced changes in elongation factor Tu conformation upon its interactions with aminoacyl transfer RNA. A fluorescence study: V.A. Dell, et al.; Biochemistry 29, 1757 (1990)
  • Conformational change of elongation factor Tu (EF-Tu) induced by antibiotic binding. Crystal structure of the complex between EF-Tu.GDP and aurodox: L. Vogeley, et al.; J. Biol. Chem. 276, 17149 (2001)
  • A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacter rodentium: K. Kimura, et al.; J. Antibiot. 64, 197 (2011)