Aurora kinase-IN-1

MedChem Express

Aurora kinase-IN-1

10

Research Use Only

C30H25Br2N3O5

667.34

Aurora kinase-IN-1 (Compound 9) is a potent inhibitor of aurora kinase. Aurora kinase-IN-1 upregulates the expression of G1 cell cycle inhibitory proteins including p21 and p27, and G1 progressive cyclin D1, and downregulates G1-to-S progressive cyclins, resulting in cell cycle arrest at the G1/S boundary. Aurora kinase-IN-1 also induces apoptosis. Aurora kinase-IN-1 is a lead compound for chemotherapeutic agents[1].

CCOC(/C(C1=O)=C/NC2=NC(C3=CC=C(C(OC)=C3)OC)=CC(C4=CC=C(C=C4)Br)=N2)OC5=C1C=C(Br)C=C5

12352200