Autophinib

MedChem Express

Autophinib [1644443-47-9]

10

1644443-47-9

Research Use Only

99.95

C14H11ClN6O3

346.73

Autophinib is a potent, selective autophagy inhibitor with IC 50 s of 90 nM and 40 nM for starvation- and Rapamycin-induced autophagy , respectively. Autophinib is also an ATP competitive Vacuolar Protein Sorting 34 (VPS34) inhibitor with an IC 50 of 19 nM. Autophinib inhibits autophagy induced by starvation or Rapamycin by targeting VPS34 [1] .

CC1=CC(NC2=NC(OC3=CC=C([N+]([O-])=O)C=C3)=NC(Cl)=C2)=NN1

-20°C,2°C to 8°C

12352200