AV-412 free base [451492-95-8]

TargetMol Chemicals

AV-412 free base [451492-95-8]

9

451492-95-8

Research Use Only

C27H28ClFN6O

507

AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).

CN1CCN(CC1)C(C)(C)C#Cc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C

-20°C

12352200