Avagacestat (Standard) [1146699-66-2]

MedChem Express

Avagacestat (Standard) [1146699-66-2]

999

Research Use Only

Avagacestat (Standard) is the analytical standard of Avagacestat. This product is intended for research and analytical applications. Avagacestat (BMS-708163) is a potent inhibitor of gamma-secretase, with IC50s of 0.27 nM and 0.30 nM for Abeta42 and Abeta40 inhibition; Avagacestat (BMS-708163) also inhibits NICD (Notch IntraCellular Domain) with IC50 of 0.84 nM and shows weak inhibition of CYP2C19, with IC50 of 20 microM. Avagacestat can be used for Alzheimer disease research.

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