Avitinib (maleate)

MedChem Express

Avitinib (maleate) [1557268-88-8]

10

1557268-88-8

99.86

C30H30FN7O6

603.60

Avitinib (Abivertinib) maleate is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC 50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R , EGFR T790M and wild-type EGFR . Avitinib maleate is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib maleate shows anticancer effects [1] [2] .

O=C(O)/C=C\C(O)=O.O=C(C=C)NC1=CC=CC(OC2=NC(NC3=CC(F)=C(N4CCN(C)CC4)C=C3)=NC5=C2C=CN5)=C1

2°C to 8°C

12352200