AVN-101 (hydrochloride) [1061354-48-0]

MedChem Express

AVN-101 (hydrochloride) [1061354-48-0]

5

1061354-48-0

Research Use Only

99.59

C21H25ClN2

340.89

AVN-101 hydrochloride is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist (Ki of 153 pM), with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors (Ki values of 2.04 nM, 1.56 nM, and 1.17 nM, respectively). AVN-101 hydrochloride also exhibits a rather high affinity toward histamine H1 (Ki of 0.58 nM) and adrenergic alpha2A, alpha2B, and alpha2C (Ki= 0.41-3.6 nM) receptors. AVN-101 hydrochloride can be studied in such diseases as general anxiety disorders, depression, schizophrenia, Alzheimers disease, and multiple sclerosis[1].

CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CC=CC=C4.[H]Cl

-20°C

12352200