Avutometinib

MedChem Express

Avutometinib [946128-88-7]

10

946128-88-7

Research Use Only

99.02

C21H18FN5O5S

471.46

Avutometinib (Ro 5126766) is a first-in-class dual MEK / RAF inhibitor that allosterically inhibits BRAF V600E , CRAF , MEK , and BRAF (IC 50 : 8.2, 56, 160 nM, and 190 nM, respectively).

O=S(NC)(NC1=NC=CC(CC2=C(C)C3=CC=C(OC4=NC=CC=N4)C=C3OC2=O)=C1F)=O

-20°C,2°C to 8°C

12352200