AX-024 [1370544-73-2]

TargetMol Chemicals

AX-024 [1370544-73-2]

14

1370544-73-2

Chemical

Research Use Only

AX-024

C21H22FNO2

339.4

AX-024 is a novel chemical compound that acts as an orally available inhibitor of the TCR-Nck interaction. Its primary mechanism of action is the selective inhibition of T cell activation triggered by TCR stimulation. With an IC50 value of approximately 1 nM, AX-024 effectively modulates cell signaling by specifically targeting SH3 domains. Additionally, AX-024 demonstrates desirable characteristics such as low acute toxicity, high potency, and excellent selectivity. Notably, it exhibits strong inhibitory effects on the production of IL-6, TNF-alpha, IFN-gamma, IL-10, and IL-17A.

3 years

COc1ccc2OCC(CN3CCCC3)=C(c3ccc(F)cc3)c2c1

-20°C

12352200