AZ 11645373

MedChem Express

AZ 11645373 [227088-94-0]

10

227088-94-0

Research Use Only

C24H21N3O5S

463.51

AZ11645373 is a highly selective and potent antagonist at human but not rat P2X7 receptors, AZ11645373 inhibits ATP-evoked IL-1beta release from lipopolysaccharide-activated THP-1 cells , with an IC 50 value of 90 nM [1] .

O=C(N1C(COC2=CC=C(C3=CC=CC([N+]([O-])=O)=C3)C=C2)CCC4=CC=NC=C4)SCC1=O

RT

12352200