AZ084

MedChem Express

AZ084 [929300-19-6]

10

929300-19-6

Research Use Only

99.65

C26H34N4O2

434.57

AZ084 is a potent, selective, allosteric and oral active CCR8 allosteric antagonist, with a K i of 0.9 nM. Has potential to treat asthma [1] . AZ084 restrains the formation of the immunologically tolerant pre-metastatic niche (PMN) and tumor cells metastasis in lung by downregulating Treg differentiation. AZ084 can be used in studies of asthma and cancer [1] [2] .

O=C(C1=NC=C(N)C=C1)N2CCC3(CCN(CC4=C5CC(C)(C)OC5=CC=C4)CC3)CC2

-20°C,2°C to 8°C

12352200