AZ1366 [1645286-58-3]

TargetMol Chemicals

AZ1366 [1645286-58-3]

72

Research Use Only

AZ1366

C24H24N4O3

416.47

AZ1366 is a potent tankyrase inhibitor that enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance. Combination AZ1366 and irinotecan achieved greater anti-tumor effects compared to monotherapy. Activity was limited to CRC explants that displayed irinotecan resistance and increased protein levels of tankyrase and NuMA.

3 years

C(O)C1=C2C(C(=O)N=C(N2)C3=CC=C(C=C3)C=4C(C)=CC(NCCOC)=NC4)=CC=C1

-20°C

12352200