AZ31 [2088113-98-6]

MedChem Express

AZ31 [2088113-98-6]

10

2088113-98-6

Research Use Only

98.13

C24H28N4O3

420.50

AZ31 is a a potent, highly selective, and orally active ATM inhibitor with an IC50 of IC50 of 46 nM for ATM in cell. AZ31 shows excellent selectivity over ATR (>500-fold) and excellent PIKK-family selectivity and pan-kinase selectivity. AZ31 is a potent radiosensitizer in vitro, it can be used for the research of cancer[1].

O=C(C1=C(N[C@@H](C)C2CCOCC2)C3=CC(C4=CC=C(COC)N=C4)=CC=C3N=C1)N

-20°C

12352200