More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/AZD-1208 [1204144-28-4]

AZD-1208 [1204144-28-4]

Research Use Only
SYN-1214
SYNkinase
CAS Number1204144-28-4
Product group Chemicals
Estimated Purity>95%
Molecular Weight379.5
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    SYNkinase
  • Product Name
    AZD1208 [1204144-28-4]
  • Delivery Days Customer
    10
  • CAS Number
    1204144-28-4
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C21H21N3O2S
  • Molecular Weight
    379.5
  • Scientific Description
    Chemical. CAS: 1204144-28-4. Formula: C21H21N3O2S. MW: 379.5. Potent, highly selective and orally available Pim kinase inhibitor that effectively inhibits all three isoforms Pim-1, Pim-2 and Pim-3 at <5nM or <150 nM in enzyme and cell assays, respectively. Potently inhibits colony growth and Pim signalling substrates in primary AML cells from bone marrow that are Flt3 wild-type or Flt3 internal tandem duplication mutants. Upregulation of Pim kinases is observed in several types of leukemias and lymphomas. Pim-1, -2 and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways. - Potent, highly selective and orally available Pim kinase inhibitor that effectively inhibits all three isoforms Pim-1, Pim-2 and Pim-3 at < 5nM or < 150 nM in enzyme and cell assays, respectively. Potently inhibits colony growth and Pim signalling substrates in primary AML cells from bone marrow that are Flt3 wild-type or Flt3 internal tandem duplication mutants. Upregulation of Pim kinases is observed in several types of leukemias and lymphomas. Pim-1, -2 and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200