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AZD2014 --- mTOR Inhibitor

BS-60090C
Bioss Antibodies
Estimated Purity98.0
Product group Chemicals
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Overview

  • Supplier
    Bioss Antibodies
  • Product Name
    AZD2014 --- mTOR Inhibitor [1009298-59-2]
  • Delivery Days Customer
    16
  • Certification
    Research Use Only
  • Estimated Purity
    98.0
  • Scientific Description
    AZD2014 is a highly potent, selective and ATP-competitive mTOR inhibitor (IC50 = 2.8 nM). It displays a high level of selectivity against other members of the PIKK family (IC50 against PI3K isoforms alpha, beta, gamma, delta = 3.8 microM, >30 microM, >30 microM and >29 microM, respectively) and is inactive against a general panel of over 200 kinases when tested at 10 microM. AZD2014 inhibits both mTORC1 and mTORC2 in vitro (pS6 (S235/236 ) IC50 = 0.2 microM, pAKT (S473) IC50 = 0.08 microM) and has shown dose-dependent tumor growth inhibition in a mouse MCF7 xenograft model alongside modulation of mTORC1 and mTORC2 biomarkers. Different from AZD8055, AZD2014 shows consistent exposure in rodents and a low turnover in human hepatocyte incubations. It is in phase I clinical development for advanced solid malignancies.
  • Storage Instruction
    -20°C
  • UNSPSC
    51202000