AZD3229

AbMole BioScience

AZD3229

9

2248003-60-1

Chemical

Research Use Only

C24H26FN7O3

479.51

AZD3229 is a potent, pan-KIT mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI50=1-50 nM), with good margin to KDR-driven effects. It also inhibits PDGFR mutants (Tel-PDGFRalfa, Tel-PDGFRbèta, V561D/D842V).

COCCOC1=CC(=C2C(=NC=NC2=C1)NC3=CC=C(NC(=O)C[N]4C=C(N=N4)C(C)C)C=C3)F

12352200