Azetukalner

MedChem Express

Azetukalner [1009344-33-5]

10

1009344-33-5

Research Use Only

99.77

C23H29FN2O

368.49

Azetukalner (XEN1101) is a selective and orally active Kv7.2/Kv7.3 potassium channel opener with an EC50 of 27 nM. Azetukalner is approximately 4-fold more selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50 of 94 nM) and Kv7.4 (EC50 of 113 nM) channels. Azetukalner exhibits a selectivity >100-fold for Kv7 channels over other ion channels and receptors. Azetukalner can be used for the study of focal epilepsy[1][2].

O=C(CC(C)(C)C)NC1=C(C)C=C(N2CC3=CC=C(C=C3CC2)F)C=C1C

-20°C,2°C to 8°C

12352200