Azide-PEG4-VC-PAB-Doxorubicin

MedChem Express

Azide-PEG4-VC-PAB-Doxorubicin

10

Research Use Only

99.62

C57H75N9O21

1222.25

Azide-PEG4-VC-PAB-Doxorubicin is a agent-linker conjugate composed of a cytotoxic anthracycline antibiotic Doxorubicin and a linker Azide-PEG4-VC-PAB to make antibody agent conjugate (ADC)[1]. Azide-PEG4-VC-PAB-Doxorubicin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

O[C@@](CC1=C2O)(C[C@@H](C1=C(C(C(C3=C4C=CC=C3OC)=O)=C2C4=O)O)O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)NC(OCC6=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)=O)C=C6)=O)C(CO)=O

-20°C,2°C to 8°C

41115800