B-355252

MedChem Express

B-355252 [1261576-81-1]

10

1261576-81-1

Research Use Only

99.0

C25H24ClN3O3S2

514.06

B355252, a phenoxy thiophene sulfonamide small molecule, is a potent NGF receptor agonist. B355252 potentiates NGF-induced neurite outgrowth. B355252 protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity, as well as in a murine hippocampal cell line (HT22) model of Parkinson disease (PD)[1].

O=S(C1=CC(Cl)=C(S1)OC2=CC=CC(N3CCNCC3)=C2)(NCC4=C5C=CC=CC5=CC=C4)=O

-20°C

12352200