B-Raf IN 9 [2477725-18-9]

MedChem Express

B-Raf IN 9 [2477725-18-9]

10

2477725-18-9

Research Use Only

C23H20N4OS

400.50

B-Raf IN 9 (compound 8b) is a potent B-Raf inhibitor, with an IC50 of 24.79 nM. B-Raf IN 9 induces apoptosis and shows cell cycle arrest at G2/M phase. B-Raf IN 9 exhibits potent antitumor activity against human prostate cancer PC-3 cell line, with an IC50 of 7.83 microM[1].

S=C(NC1=CC=CC=C1)NC2=CC=C(C(CC3)=NN(C4=CC=CC=C4)C3=O)C=C2

12131703