B-Raf (V600E Mutant Specific) antibody [RM8]

GeneTex

B-Raf (V600E Mutant Specific) antibody [RM8] - Orthogonal Validated

9

This antibody reacts to the BRAF V600E mutant. No cross reactivity with wild type BRAF.

WB: 0.5 - 2 microg/mL. ICC/IF: 0.5 - 5 microg/mL. IHC-P: 0.5 - 5 microg/mL. ELISA: 0.5 - 2 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

RM8

Unconjugated

BRAF

B-Raf proto-oncogene, serine/threonine kinase

94 kDa B-raf protein; B-raf; B-Raf proto-oncogene serine/threonine-protein kinase (p94); B-Raf serine/threonine-protein; BRAF1; B-RAF1; murine sarcoma viral (v-raf) oncogene homolog B1; NS7; proto-oncogene B-Raf; RAFB1; serine/threonine-protein kinase B-raf; v-raf murine sarcoma viral oncogene homolog B; v-raf murine sarcoma viral oncogene homolog B1

Rabbit

IgG

Serine/threonine-protein kinase B-raf

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]

Human

-20°C or -80°C,2°C to 8°C

12352203