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B2M (Human) CRISPR/Cas9 Lentivirus (Non-Integrating)

B2M (Human) CRISPR/Cas9 Lentivirus (Non-Integrating)

Research Use Only
78341
BPS Bioscience
Product group Molecular Biology
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Overview

  • Supplier
    BPS Bioscience
  • Product Name
    B2M (Human) CRISPR/Cas9 Lentivirus (Non-Integrating)
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Scientific Description
    Beta-2 Microglobulin (B2M) is a required component of Major Histocompatibility Complex (MHC) class 1 molecules, which present peptide fragments from within the cell to cytotoxic T-cells as part of the adaptive immune system. The B2M CRISPR/Cas9 Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a CRISPR/Cas9 gene driven by an EF1a promoter, along with 5 sgRNA (single guide RNAs) targeting human B2M driven by a U6 promoter. The integrating lentivirus integrates randomly into the cellular genome to express both Cas9 and the sgRNA. Puromycin selection forces high expression levels of both Cas9 and the sgRNA, and can be used with the integrating lentivirus to quickly and easily achieve high knockdown efficiencies in a cell pool. Efficiencies will depend on the cell type and the gene of interest.
  • Storage Instruction
    -80°C
  • UNSPSC
    41106621

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References
BPS Bioscience
Protein IDP55899
  • SizePrice
B2M (Human) CRISPR/Cas9 Lentivirus (Integrating)
Product group Molecular Biology
BPS Bioscience
  • SizePrice