BACE1-IN-12 [2479315-19-8]

MedChem Express

BACE1-IN-12 [2479315-19-8]

10

2479315-19-8

Research Use Only

C29H28Cl2N6O

547.48

BACE1-IN-12 (compound 7g) is a potent and BBB-penetrated BACE1 inhibitor, with an IC50 of 8.9 microM. BACE1-IN-12 shows selective BuChE (butyrylcholinesterase) inhibitory activity with an IC50 of 3.2 microM. BACE1-IN-12 shows effective antioxidant effect with an IC50 of 10.2 microM (DPPH). BACE1-IN-12 might be served as a potential anti-Alzheimer agent[1].

ClC1=CC=C(CN2N=NC(COC3=CC=C(C4=C(NC5CCCCC5)N6C=CC=CC6=N4)C=C3)=C2)C=C1Cl

12131703