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BAFF Receptor peptide

GTX26086
GeneTex
ApplicationsNeutralisation/Blocking
Product group Proteins / Signaling Molecules
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Overview

  • Supplier
    GeneTex
  • Product Name
    BAFF Receptor peptide
  • Delivery Days Customer
    9
  • Application Supplier Note
    The peptide is used for blocking the antibody activity of anti-BAFFR (cat. No GTX25965). It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37C.
  • Applications
    Neutralisation/Blocking
  • Certification
    Research Use Only
  • Concentration
    0.20 mg/ml
  • Conjugate
    Unconjugated
  • Scientific Description
    Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kappaB and c-jun N terminal kinase.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352202