Bafilomycin A1

MedChem Express

Bafilomycin A1 [88899-55-2]

10

88899-55-2

99.95

C35H58O9

622.83

Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H + -ATPase ( V-ATPase ) with IC 50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis [1] [2] [3] .

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-20°C

12352200