BAK antibody [N1N2], N-term
GTX100063
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetBAK1
Overview
- SupplierGeneTex
- Product NameBAK antibody [N1N2], N-term
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID578
- Target nameBAK1
- Target descriptionBCL2 antagonist/killer 1
- Target synonymsBAK, BAK-LIKE, BCL2L7, CDN1, bcl-2 homologous antagonist/killer, BCL2-like 7 protein, apoptosis regulator BAK, bcl-2-like protein 7, bcl2-L-7, pro-apoptotic protein BAK
- HostRabbit
- IsotypeIgG
- Protein IDQ16611
- Protein NameBcl-2 homologous antagonist/killer
- Scientific DescriptionThe protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Lee CW, Huang CC, Chi MC, et al. Naringenin Induces ROS-Mediated ER Stress, Autophagy, and Apoptosis in Human Osteosarcoma Cell Lines. Molecules. 2022,27(2). doi: 10.3390/molecules27020373Read this paper
- Lepelley A, Della Mina E, Van Nieuwenhove E, et al. Enhanced cGAS-STING-dependent interferon signaling associated with mutations in ATAD3A. J Exp Med. 2021,218(10). doi: 10.1084/jem.20201560Read this paper
- Chen YH, Yang SF, Yang CK, et al. Metformin induces apoptosis and inhibits migration by activating the AMPK/p53 axis and suppressing PI3K/AKT signaling in human cervical cancer cells. Mol Med Rep. 2021,23(1):pii: 88. doi: 10.3892/mmr.2020.11725.Read this paper
- Lee CW, Chi MC, Chang TM, et al. Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species. J Cell Physiol. 2019,234(8):13157-13168. doi: 10.1002/jcp.27986Read this paper
- Chen PH, Chang CK, Shih CM, et al. The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death. Neuropharmacology. 2016,110(Pt A):362-375. doi: 10.1016/j.neuropharm.2016.07.038Read this paper
- Chen MF, Huang SJ, Huang CC, et al. Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells. BMC Cancer. 2016,16:532. doi: 10.1186/s12885-016-2599-0Read this paper
- Lin MH, Cheng CH, Chen KC, et al. Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells. Chem Biol Interact. 2014,218:42-9. doi: 10.1016/j.cbi.2014.04.015Read this paper
Datasheet
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