Balanol [63590-19-2]

MedChem Express

Balanol [63590-19-2]

10

63590-19-2

Research Use Only

C28H26N2O10

550.51

Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes alpha, beta-I, beta-II, gamma, delta, epsilon, eta (IC50s=4-9 nM) and aeta (IC50=150 nM). Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS). Balanol can be isolated from the fungus Verticillium balanoides[1][2].

O=C(C1=C(C=C(C(O[C@H]2[C@@H](CNCCC2)NC(C3=CC=C(O)C=C3)=O)=O)C=C1O)O)C4=C(C=CC=C4O)C(O)=O

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