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Bardoxolone [218600-44-3]

HY-14909
MedChem Express
CAS Number218600-44-3
Product group Chemicals
Estimated Purity99.50
Molecular Weight491.66
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Bardoxolone [218600-44-3]
  • Delivery Days Customer
    10
  • CAS Number
    218600-44-3
  • Certification
    Research Use Only
  • Estimated Purity
    99.50
  • Molecular Formula
    C31H41NO4
  • Molecular Weight
    491.66
  • Scientific Description
    Bardoxolone (RTA 401; CDDO) is an orally active activator of nuclear regulatory factor (NRf-2) and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone inhibits SARS-CoV-2 3CL protease with an EC50 value of 0.43 microM in vero cells. Bardoxolone also inhibits necroptosis in HT-29 cells with an EC50 value of 1.30 microM by blocking necrosome formation through inhibiting phosphorylation of RIPK1 and RIPK3. Bardoxolone can be used in research on COVID-19, TNF-induced systemic inflammatory response syndrome (SIRS), and cerebral ischemia-reperfusion injury[1][2].
  • SMILES
    CC1(C)CC[C@@]2(C(O)=O)[C@@]([C@](C(C=C3[C@@]4(C)CC[C@]5([H])[C@]3(C)C=C(C#N)C(C5(C)C)=O)=O)([H])[C@@]4(C)CC2)([H])C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12131703

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