Bardoxolone [218600-44-3]
HY-14909
Overview
- SupplierMedChem Express
- Product NameBardoxolone [218600-44-3]
- Delivery Days Customer10
- CAS Number218600-44-3
- CertificationResearch Use Only
- Estimated Purity99.50
- Molecular FormulaC31H41NO4
- Molecular Weight491.66
- Scientific DescriptionBardoxolone (RTA 401; CDDO) is an orally active activator of nuclear regulatory factor (NRf-2) and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone inhibits SARS-CoV-2 3CL protease with an EC50 value of 0.43 microM in vero cells. Bardoxolone also inhibits necroptosis in HT-29 cells with an EC50 value of 1.30 microM by blocking necrosome formation through inhibiting phosphorylation of RIPK1 and RIPK3. Bardoxolone can be used in research on COVID-19, TNF-induced systemic inflammatory response syndrome (SIRS), and cerebral ischemia-reperfusion injury[1][2].
- SMILESCC1(C)CC[C@@]2(C(O)=O)[C@@]([C@](C(C=C3[C@@]4(C)CC[C@]5([H])[C@]3(C)C=C(C#N)C(C5(C)C)=O)=O)([H])[C@@]4(C)CC2)([H])C1
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12131703