BAY-3827 [2377576-35-5]

MedChem Express

BAY-3827 [2377576-35-5]

10

2377576-35-5

Research Use Only

99.72

C27H25FN6O

468.53

BAY-3827 is a potent and selective AMPK inhibitor with IC50 values of 1.4 nM at low (10 microM ATP concentration) and 15 nM at high (2 mM ATP concentration). BAY-3827 shows over 500-fold selectivity for most of the 331 kinases. BAY-3827 prevents phosphorylation of acetyl-CoA carboxylase 1 and shows strongest anti-proliferative activity in androgen-dependent prostate cancer cell lines[1].

CCC1=CC=CC=C1C(NC2=NNC3=C2C=C(C4C(C#N)=C(C)N(C)C(C)=C4C#N)C(F)=C3C)=O

2°C to 8°C

12352200