BAY 87-2243 --- Hypoxia-inducible Factor-1 (HIF-1) Inhibitor

Bioss

BAY 87-2243 --- Hypoxia-inducible Factor-1 (HIF-1) Inhibitor [1227158-85-1]

16

Research Use Only

98.0

BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation, which has antitumor activities by inhibition of mitochondrial complex I. BAY 87-2243 mproves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts. BAY-87-2243 markedly decreased nuclear HIF-1alpha expression and pimonidazole hypoxic fraction already after 3 days of drug treatment. BAY-87-2243 prior to RT significantly reduced TCD50 from 123 to 100 Gy (p=0.037). Additional BAY-87-2243 application during RT did not decrease TCD50.

-20°C

51202000