BAY-958 [1335490-39-5]
HY-121081
CAS Number1335490-39-5
Product group Chemicals
Molecular Weight389.40
Overview
- SupplierMedChem Express
- Product NameBAY-958 [1335490-39-5]
- Delivery Days Customer5
- CAS Number1335490-39-5
- CertificationResearch Use Only
- Molecular FormulaC17H16FN5O3S
- Molecular Weight389.40
- Scientific DescriptionBAY-958 is a potent PTEFb/CDK9 inhibitor with high selectivity demonstrated in vitro, particularly within the CDK family. It shows strong antiproliferative activity against cancer cell lines such as HeLa and MOLM-13. In pharmacokinetic studies, BAY-958 exhibited good metabolic stability but had low aqueous solubility and moderate permeability, leading to challenges in bioavailability. Despite these limitations, BAY-958 hydrochloride effectively inhibited tumor growth in mouse xenograft models without significant toxicity, indicating promising efficacy in vivo. However, its suboptimal physicochemical properties prompted further development efforts to identify compounds with improved overall characteristics for potential clinical use[1].
- SMILESO=S(CC1=CC=CC(NC2=NC(C3=CC=C(F)C=C3OC)=NC=N2)=C1)(N)=O
- UNSPSC12352200