BAY1125976

Selleck Chemicals

BAY1125976

9

Research Use Only

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BAY 1125976 is a selective allosteric AKT1/2 inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1 (IC50 = 5.2 nM at 10 microM ATP and 44 nM at 2 mM ATP) and AKT2 (IC50 = 18 nM at 10 microM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3 (IC50 = 427 nM at 10 microM ATP).

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