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BBT594 [882405-89-2]

Research Use Only
SYN-1225
SYNkinase
CAS Number882405-89-2
Product group Chemicals
Estimated Purity>95%
Molecular Weight569.6
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Overview

  • Supplier
    SYNkinase
  • Product Name
    BBT594 [882405-89-2]
  • Delivery Days Customer
    10
  • CAS Number
    882405-89-2
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C28H30F3N7O3
  • Molecular Weight
    569.6
  • Scientific Description
    BBT594 (NVP-BBT594) is a potent and selective inhibitor of RET and JAK2. BBT594 impairs glial-derived neurotrophic factor (GDNF)-RET signaling and GDNF-dependent growth in specific in vitro models. Direct inhibition of GDNF-RET signaling by BBT594 in ER+ breast cancer cells enhances the sensitivity to aromatase inhibitor (AI) treatment and reverts AI resistance. In murine models, the IC50 of BBT594 on JAK2 inhibition varies between 8nM - 29nM, depending on the cell model and abundant JAK2 mutations. - Chemical. CAS: 882405-89-2. Formula: C28H30F3N7O3. MW: 569.6. BBT594 (NVP-BBT594) is a potent and selective inhibitor of RET and JAK2. BBT594 impairs glial-derived neurotrophic factor (GDNF)-RET signaling and GDNF-dependent growth in specific in vitro models. Direct inhibition of GDNF-RET signaling by BBT594 in ER+ breast cancer cells enhances the sensitivity to aromatase inhibitor (AI) treatment and reverts AI resistance. In murine models, the IC50 of BBT594 on JAK2 inhibition varies between 8nM - 29nM, depending on the cell model and abundant JAK2 mutations.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    51202000