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BC-1215

M57279
AbMole BioScience
CAS Number1507370-20-8
Product group Chemicals
Molecular Weight394.51
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    BC-1215
  • Delivery Days Customer
    9
  • CAS Number
    1507370-20-8
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Molecular Formula
    C26H26N4
  • Molecular Weight
    394.51
  • Scientific Description
    BC-1215 is a novel inhibitor of F-box protein 3 (Fbxo3) activity. BC-1215 works by antagonizing of Fbxo3 on TRAF cytokine signaling and exhibits a low IC50 in vitro. BC-1215 relieves allodynia by preventing ubiquitination-dependent Fbxl2/TRAF2/TNIK/pGluR1 signaling. BC-1215 exerted robust therapeutic effects in cytokine-driven inflammation, including pseudomona-induced lung injury and cecum ligation/punctured-induced sepsis, by targeting Fbxo3/Fbxl2/TRAF-mediated cytokine release. BC-1215 can be used for the research of inflammation.
  • SMILES
    C1=CC=NC(=C1)C2=CC=C(C=C2)CNCCNCC3=CC=C(C=C3)C4=CC=CC=N4
  • UNSPSC
    12352200

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