BCAR3 blocking peptide

GeneTex

BCAR3 blocking peptide

9

Neutralisation/Blocking

Research Use Only

200 ug/ml

Unconjugated

BCAR3

BCAR3 adaptor protein, NSP family member

AND-34, MIG7, NSP2, SH2D3B, breast cancer anti-estrogen resistance protein 3, BCAR3, NSP family adaptor protein, SH2 domain-containing protein 3B, breast cancer anti-estrogen resistance 3, breast cancer antiestrogen resistance 3 protein, dJ1033H22.2 (breast cancer anti-estrogen resistance 3), epididymis secretory sperm binding protein, mig-7, migration inducting gene-7, novel SH2-containing protein 2

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

-20°C

41116100

Human