BChE-IN-8 [2653349-78-9]
HY-147859
CAS Number2653349-78-9
Product group Chemicals
Molecular Weight438.24
Overview
- SupplierMedChem Express
- Product NameBChE-IN-8 [2653349-78-9]
- Delivery Days Customer10
- CAS Number2653349-78-9
- CertificationResearch Use Only
- Molecular FormulaC18H12BrN7O2
- Molecular Weight438.24
- Scientific DescriptionBChE-IN-8 (compound 20) is an orally active, potent and BBB-penetrated BChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.15 nM (eqBChE, equine serum BChE) and 45.2 nM (hBChE), respectively. High stability of BChE-IN-8 contributes to significantly improved blood concentration and tissue exposure. BChE-IN-8 can exert neuro-protecting and cognition improving properties through multiple modulations, including cholinergic system, Abeta aggregation, neuropeptide levels. BChE-IN-8 can be used for Alzheimers disease (AD) research[1].
- SMILESO=C(NC1=CC(C#N)=CC(Br)=C1)CN2C3=CC=CC=C3N=C2C4=NON=C4N
- UNSPSC12131703