BCL2A1 Antibody

Cusabio

BCL2A1 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

BCL2A1

BCL2 related protein A1

ACC1; ACC-1; ACC2; ACC-2; BCL2L5; bcl2-L-5; bcl-2-like protein 5; bcl-2-related protein A1; BFL1; GRS; HBPA1; hematopoietic BCL2-related protein A1; hemopoietic-specific early response protein; protein BFL-1

Rabbit

IgG

Bcl-2-related protein A1

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Human, Mouse

-20°C or -80°C

41116161