Becatecarin

Biorbyt

Becatecarin [119673-08-4]

10

119673-08-4

Research Use Only

98.00%

C33H34Cl2N4O7

669.56

Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis. Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo. It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2.

CCN(CC)CCN1C(=O)c2c(C1=O)c1c3cccc(Cl)c3n([C@@H]3O[C@H](CO)[C@@H](OC)[C@H](O)[C@H]3O)c1c1[nH]c3c(Cl)cccc3c21

-20°C

12352200