Benzomalvin C [157047-98-8]

MedChem Express

Benzomalvin C [157047-98-8]

5

157047-98-8

Research Use Only

C24H17N3O3

395.41

Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 microg/mL in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 microM for recombinant IDO. It is isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.

O=C1C2=C(N=C3N1C4=C(C(N([C@]35O[C@@H]5C6=CC=CC=C6)C)=O)C=CC=C4)C=CC=C2

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