Bio-Connect

BET-IN-20

HY-149735
MedChem Express
Molecular Weight412.48
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    BET-IN-20 [1300735-76-5]
  • Delivery Days Customer
    14
  • Certification
    Research Use Only
  • Molecular Formula
    C25H24N4O2
  • Molecular Weight
    412.48
  • Scientific Description
    BET-IN-20 (compound 10) is an inhibitor of BRD4 BD1 (IC50=1.9 nM) with anticancer activity. BET-IN-20 can promote acute myeloid leukemia (AML) cell apoptosis and arrest the cell cycle in the G0/G1 phase. BET-IN-20 also inhibits c-Myc and CDK6 and enhances PARP cleavage[1].
  • SMILES
    C[C@H](C1=CC=CC=C1)N2C(C3=C4)=C(N=C2C)C=NC3=CC(C5=C(C)ON=C5C)=C4OC
  • UNSPSC
    12131703