beta Defensin 3 antibody

GeneTex

beta Defensin 3 antibody

9

Reacts with residues 23-33 [GIINTLQKYYC] of the 5-kDa human beta-defensin-3 protein.

Western blot - Use at 1:500 to 1:1,000 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Western Blot

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Liquid

Rabbit

IgG

A novel, nonhemolytic antimicrobial peptide (human beta-defensin-3, hBD-3) was isolated from human lesional psoriatic scales and cloned from keratinocytes. hBD-3 demonstrated a salt-insensitive broad spectrum of potent antimicrobial activity against many potentially pathogenic microbes including multiresistant S. aureus and vancomycin-resistant Enterococcus faecium. Keratinocytes and airway epithelial cells are cellular sources of hBD-3. Tumor necrosis factor alpha and contact with bacteria were found to induce hBD-3 mRNA expression. hBD-3 therefore might be important in the innate epithelial defense of infections by various microorganisms seen in skin and lung, such as cystic fibrosis.

Human

-20°C or -80°C,2°C to 8°C

12352203