beta-Glu-PAB(CH2NH2)-Exatecan

MedChem Express

beta-Glu-PAB(CH2NH2)-Exatecan

999

Research Use Only

96.60

C39H39FN4O13

790.74

beta-Glu-PAB(CH2NH2)-Exatecan (Compound 9a) is a topoisomerase I inhibitor. beta-Glu-PAB(CH2NH2)-Exatecan binds to the topoisomerase I-DNA complex to prevent DNA strand reconnection, thereby inducing DNA breakage and cell apoptosis. beta-Glu-PAB(CH2NH2)-Exatecan can be specifically cleaved by beta-glucuronidase highly expressed in the tumor microenvironment to release Exatecan for cytotoxic effect. beta-Glu-PAB(CH2NH2)-Exatecan is also an intermediate of Mal((3S,3aR,6S,6aR) -hexahydrofuro [3, 2-B]furan-3,6-diamine-PEG12)-beta -Glu-Pab-Exatecan. beta-Glu-PAB(CH2NH2)-Exatecan is promising for research of cancers[1].

NCC(C=C1COC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=C(C=C1)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O

-20°C

41115800