beta-Glucuronidase-IN-3

MedChem Express

beta-Glucuronidase-IN-3 [3081681-34-4]

5

Research Use Only

C10H7N3OSe

264.14

beta-Glucuronidase-IN-3 (Compound 49) is a covalent allosteric beta-glucuronidase inhibitor. beta-Glucuronidase-IN-3 has potent inhibitory activity against Escherichia coli beta-glucuronidase (EcGUS) (IC50: 12.9 nM). beta-Glucuronidase-IN-3 exerts its inhibitory effect by reversibly covalently modifying the cysteine residues (Cys28, Cys443, and Cys197) of EcGUS. beta-Glucuronidase-IN-3 can be used in the study of intestinal microbiota-related diseases, especially to alleviate the toxic side effects of Irinotecan (HY-16562) and nonsteroidal anti-inflammatory drugs (NSAIDs)[1].

O=C1N(C2=CNN=C2)[Se]C3=CC=CC=C31

12352200